目的　比较奇宁注射液 (斑蝥酸钠注射液 )联合氟脲嘧啶、亚叶酸钙 (治疗组 )与传统大肠癌化疗方案 (对照组 )治疗大肠癌的疗效及毒性。方法　治疗组 3 8例 ,奇宁 (SodiumCantharidate) 0 3mg ,亚叶酸钙 (CF) 2 0 0mg/m2 ,5 -氟尿嘧啶 ( 5 -Fu) 3 75mg/m2静脉滴注第 1～ 10d ;对照组 3 8例 ,CF 2 0 0mg/m2 ,5 -Fu3 75mg/m2 静脉滴注第 1～ 10d。结果　治疗组有效率 ( 3 9 5 %) ,高于对照组( 18 4%) ,统计学上有显著性差异 (P <0 0 5 ) ;血液学毒副作用治疗组明显低于对照组 (P <0 0 5 )。结论　该研究表明 ,奇宁联合5 -Fu和CF治疗大肠癌患者 ,缓解率较高 ,毒性相对较弱 ,值得进一步临床研究 Objective To compare the curative effect and toxicity of Qi Ning injection (sodium cantharidate injection) combined with fluorouracil, leucovorin (treatment group) and traditional colorectal cancer chemotherapy (control group) in the treatment of colorectal cancer. Methods In the treatment group, 38 cases were treated with sodium cantharidate 0 mg, calcium leucovorin 200 mg / m2, and 5-fluorouracil 5 75 mg / m2 intravenously for 1 ~ 10 days. In control group 3 8 cases, CF 2 0 0mg / m2, 5-Fu 3 75mg / m2 intravenous drip 1 ~ 10d. Results The effective rate of the treatment group (395%) was higher than that of the control group (18.4%), and there was a statistically significant difference (P <0.05); the hematological toxicities and side effects were significantly lower in the treatment group than in the control group <0 0 5). Conclusion This study shows that the combination of Qining and 5-Fu and CF in the treatment of colorectal cancer patients with high remission rate and relatively weak toxicity, it is worth further clinical study