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环孢素A(Cyclosporin A, Cy-A)是一种新的比较强的免疫抑制剂,它可以提高尸体移植肾存活率15～20%.但Cy-A有明显肾毒性,Cy-A肾中毒和排异的临床表现很相似,可以单独存在,也可以二者共存.由干两者处理截然不同,所以正确诊断是非常重要的,但目前尚无一个明确的客观标准,主要根据临床表现和实验室检查.下面分几个方面加以综述.Cy-A肾中毒临床表现和Cy-A血浓度测定Cy-A肾中毒临床可以分为三型:(1)剂量依赖性肾中毒;(2)交叉性肾中毒;(3)慢性肾中毒.
Cyclosporin A (Cy-A) is a new and stronger immunosuppressive agent, which can improve the survival rate of cadaveric allograft kidneys by 15-20%. However, Cy-A has obvious nephrotoxicity and Cy-A The clinical manifestations of poisoning and rejection are very similar and can exist alone or both.The treatment is very different from the dry two, so the correct diagnosis is very important, but there is no clear objective criteria, mainly based on clinical manifestations And laboratory tests are summarized below.Cy-A nephrotoxic clinical manifestations and determination of Cy-A blood concentration Cy-A nephrotoxicity clinical can be divided into three types: (1) dose-dependent renal toxicity; (2 ) Cross-renal disease; (3) chronic kidney poisoning.