铁是生命过程必需的,但是铁本身的化学特性决定了它的潜在生物毒性。游离铁可通过Fenton反应产生自由基引起细胞凋亡或坏死。中枢神经系统缺乏天然的抗氧化物谷胱甘肽,且铁是脑中最丰富的过渡金属,所以铁的代谢异常很可能引起中枢神经系统病变。本文回顾了近几年的研究报道,主要阐述铁的生物特性在中枢神经变性疾病中的作用。 Iron is necessary for life processes, but its own chemical properties determine its potential biological toxicity. Free iron can generate free radicals by Fenton reaction to cause apoptosis or necrosis. The central nervous system lacks the natural antioxidant glutathione, and iron is the most abundant transition metal in the brain, so iron metabolism is likely to cause central nervous system disorders. This article reviews the reports of recent years and mainly discusses the role of iron biological characteristics in CNS degenerative diseases.