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目的探讨白蛋白对脂肪栓塞综合征的防治作用。方法实验共用２１只健康杂种犬，建立脂肪栓塞综合征模型。于各时间点检测动脉血氧分压、血浆白蛋白和游离脂肪酸，并在栓塞后４８小时处死动物，取肺组织进行病理学检查和肺重量／肺系数测定。结果对照组和治疗组均有脂肪栓塞综合征发生，预防组则未发生脂肪栓塞综合征。结论白蛋白对脂肪栓塞综合征的防治作用取决于应用的时间，栓塞后早期应用白蛋白可以预防脂肪栓塞综合征的发生，栓塞１２小时以后再应用白蛋白治疗脂肪栓塞综合征是无效的。
Objective To investigate the prevention and treatment of albumin on fat embolism syndrome. Methods A total of 21 healthy mongrel dogs were used to establish the model of fat embolism syndrome. The arterial oxygen pressure, plasma albumin and free fatty acids were measured at various time points. Animals were sacrificed at 48 hours after embolization. Pulmonary tissues were taken for pathological examination and lung weight / lung coefficient determination. Results Both the control group and the treatment group had fat embolism syndrome, while the prevention group did not have fat embolism syndrome. Conclusions The preventive and therapeutic effects of albumin on fat embolism syndrome depends on the time of application. The early application of albumin after embolization can prevent the occurrence of fat embolism syndrome. The treatment of fat embolism syndrome after 12 hours of embolization is ineffective.