MDM2 is Implicated in High Glucose induced Podocyte Mitotic Catastrophe via Numb/Notch1 Signaling

来源 :2016年国际生理学学术大会 | 被引量 : 0次 | 上传用户：wuhu001

【摘要】

：

Background: Podocyte injury and depletion are essential events involved in the pathogenesis of diabetic nephropathy(DN).As a terminally differentiated cell,podocyte is restricted in ‘post-mitosis stat

【作者】

：

Hui Tang Hua Su Chun Zhang

【机构】

：

Department of Nephrology,Union Hospital,Tongji Medical College,Huazhong University of Science and Te

【出处】

：

2016年国际生理学学术大会

【发表日期】

：

2016年6期

【关键词】

：

MDM2 Mitotic catastrophe podocyte injury Notch

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

EGF-mobilized intracellular calcium of cumulus cells decreases NPR2 affinity for NPPC and induces oo

Natriuretic peptide type C(NPPC)activation of the guanylyl cyclase-linked natriuretic peptide receptor 2(NPR2)maintains oocyte meiotic arrest.Luteinizing hormone(LH)-dependent epidermal growth factor(

会议

Epidermal growth factorCalciumNatriuretic peptide receptor 2Affinity

NBCn1 represents a novel mechanism for HCO3-absorption in endometrial epithelium

pH regulation affects a series of processes during mammalian reproduction,such as sperm capacitation,fertilization,embryo implantation,and early development.The uterine fluid is rich in HCO3 –.During

会议

bicarbonate transporterendometrial epitheliumestrous cycleestradiol

C-Type Natriuretic Peptide plays a crucial role in regulation of ovulation in Polycystic ovary syndr

Polycystic ovary syndrome(PCOS)is a complex endocrinopathy which affects 5%-7%of reproductive-age womens fertility.However,the specific causes of anovulation are still not well clarified.Natriuretic p

会议

AndrogenNatriuretic peptide receptor 2anovulatoryPCOS

Sp1 regulates primordial folliculogenesis through Notch2-dependent pathways in mouse

Establishment of the pool of primordial follicles each consisting of an oocyte surrounded by a layer of somatic cells is essential for mammalian fertility.However,very little is known about the breakd

会议

Sp1primordial folliculogenesisNotch2

HDAC mediates LH action on regulating oocytes maturation through repressing AREG expression

LH regulation of the EGF network is essential for oocytes maturation and the ovulatory process.The mechanisms underlying transcription of EGF-like factors are,however,poorly understood.Acting an impor

会议

HDACAREGoocytes maturation

Effect of PIPP on Phosphorylated CDC2 at Tyr15 by AKT Pathway During Meiotic Resumption of Mouse Ooc

Proline-rich inositol polyphosphate 5-phosphatase(PIPP)may inhibit AKT activity by hydrolyzing the 5-phosphate of phosphatidylinositol [PtdIns(3,4,5)3] to block the interaction of PtdIns(3,4,5)3 with

会议

proline-rich inositol polyphosphate 5-phosphatase (PIPP)protein kinase B (PKB/A

Role of GSK3β in Maintaining Germ Cell Survival during Meiotic Prophase Ⅰ in mice fetal ovary

Female mammalians have a limited reproduction lifespan,since germ cells are generated merely during fetal life,then followed by continues depletion during adult life.Thus,research on mechanisms regula

会议

GSK3βmeiosisDSBs repairgerm cell loss

Antioxidant role of Beta Carotene:Protection against cadmium induced testicular toxicity

Cadmium(Cd)is an industrial pollutant that affects the male reproductive system.The purpose of present study was to investigate the protective role of Beta carotene on cadmium induced testicular damag

会议

Cadmiumoxidative stressbeta-carotenelipid peroxideglutathione

Exogenous Hydrogen Sulfide Ameliorates Fetal Growth Retardation Induced by in Utero Cigarette Smoke

It has been shown that in utero cigarette smoke exposure(CSE)may result in a variety of adverse developmental outcomes,with fetal intrauterine growth retardation being well documented.Hydrogen sulfide

会议

hydrogen sulfideintrauterine growth retardationin utero cigarette smoke exposu

Activation of Kir4.1 is essential for activating thiazide-sensitive NaCl cotransporter(NCC)in the DC

Kir.4.1(Kcnj10)is an inwardly-rectifying K channel expressed in the basolateral membrane of distal convoluted tubule(DCT).Loss-of-function mutations of Kir4.1 cause EAST or SeSAME syndrome and the ren

会议

Kir4.1NCCDCT

MDM2 is Implicated in High Glucose induced Podocyte Mitotic Catastrophe via Numb/Notch1 Signaling

其他学术论文