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  5. The Interleukin-6 Classic-and Trans-Signaling are Both Implicated in High Glucose induced Podocyte I

The Interleukin-6 Classic-and Trans-Signaling are Both Implicated in High Glucose induced Podocyte I

来源 :2016年国际生理学学术大会 | 被引量 : 0次 | 上传用户：zxcfs
【摘 要】
：
Background: Interleukin 6(IL-6)is a pleiotropic cytokine that has both pro-and anti-inflammatory properties via the membrane bound IL-6R(classical IL-6 signaling)or the soluble IL-6R(IL-6 trans-signal
【作 者】
：
Chun-Tao Lei Hua Su Chun Zhang 
【机 构】
：
Department of Nephrology,Union Hospital,Tongji Medical College,Huazhong University of Science and Te
【出 处】
：
2016年国际生理学学术大会
【发表日期】
：
2016年6期
【关键词】
：
Inflammation Interlukin-6(IL-6) STAT3 Podocyte 
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　　Background: Interleukin 6(IL-6)is a pleiotropic cytokine that has both pro-and anti-inflammatory properties via the membrane bound IL-6R(classical IL-6 signaling)or the soluble IL-6R(IL-6 trans-signaling).Inflammation is a cardinal pathogenetic mechanism in diabetic nephropathy(DN).However,the roles of IL-6 classic-and trans-signaling in high glucose-(HG-)induced podocyte injury remain unclear.
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