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目的了解携带耐消毒剂磺胺复合物基因qacE△1-sul1的多药耐药革兰阴性杆菌临床分布状况,为多药耐药革兰阴性杆菌医院感染预防控制提供依据。方法采用聚合酶链反应(PCR)检测多药耐药革兰阴性杆菌qacE△1-sul1基因,分析其阳性菌株的分布特点。结果182株qacE△1-sul1基因阳性多药耐药革兰阴性杆菌临床分布以重症监护病房(ICU)最多(55株,30.22%),其次为普外科(38株,20.88%);标本分布以痰标本检出率最高(52.20%)。结论耐消毒剂基因qacE△1-sul1多药耐药革兰阴性杆菌分布以ICU、普外科较高,应作为防范重点,加强医院环境微生物监测,防止感染携带耐消毒剂基因多药耐药菌感染的局部流行和暴发。
Objective To investigate the clinical distribution of multidrug-resistant Gram-negative bacilli carrying qacE △ 1-sul1, an anti-disinfectant sulfonamide complex gene, and provide evidence for the prevention and control of multidrug-resistant Gram-negative bacilli in hospital. Methods Polymerase chain reaction (PCR) was used to detect the qacE △ 1-sul1 gene of multidrug-resistant Gram-negative bacilli. The distribution characteristics of the strains were analyzed. Results The clinical distribution of 182 strains of multidrug-resistant gram-negative bacilli with qacE △ 1-sul1 gene in ICU was the highest (55 strains, 30.22%), followed by general surgery (38 strains, 20.88%). Specimens distribution The highest detection rate of sputum specimens (52.20%). Conclusion The multidrug-resistant gram-negative bacilli with qacE △ 1-sul1, a disinfectant-resistant gene, distributed in ICU and general surgery, should be taken as a precautionary focus to strengthen the monitoring of micro-organisms in the hospital environment and prevent the infection of multi-drug resistant bacilli Local epidemics and outbreaks of infection.